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Unregistered
15-11-07, 01:17
Researchers get stem cells from cloned monkeys


(Updates with quotes from researcher, details)

By Maggie Fox, Health and Science Editor

WASHINGTON, Nov 14 (Reuters) - U.S. researchers have cloned monkeys and used the resulting embryos to get embryonic stem cells, an important step towards being able to do the same thing in humans, they reported on Wednesday.

Shoukhrat Mitalipov and colleagues at Oregon Health & Science University said they used skin cells from monkeys to create cloned embryos, and then extracted embryonic stem cells from these days-old embryos.

This had only been done in mice before, they reported in the journal Nature. Mitalipov had given sketchy details of his work at a conference in Australia in June, but the work has now been independently verified by another team of experts.

They said their work shows it is possible, in principle, to clone humans and get stem cells from the embryos. "The efficiency is still low but I am quite sure that it will work in humans," Mitalipov told reporters in a telephone briefing.

Embryonic stem cells are the source of every cell, tissue and organ in the body. Scientists study them to understand the biology of disease and want to use them to transform medicine.

The idea would be to take a small piece of skin from a patient and grow tissue or even organ transplants perfectly matched to the patient.

But their use is controversial, with opponents saying it is wrong to use a human embryo in this way. U.S. President George W. Bush has repeatedly blocked legislation that would expand federal funding of such research.

OVERCOMING BARRIERS

Many species of animals have been cloned, and experts have taken stem cells from a variety of embryos, including human embryos. But it has been very difficult to both clone and then get embryonic stem cells from any animal.

Mitalipov's team overcame two barriers -- first cloning a primate, the group of mammals that includes monkeys, apes and humans, and then getting embryonic stem cells from the clone.

Mitalipov said the dyes used in cloning some animals apparently are toxic to primate cells.

They used somatic cell nuclear transfer, which involves taking the nucleus from an adult cell, in this case fibroblasts, a type of skin cell, taken from nine adult males.

Then an egg cell is hollowed out and the nucleus from the adult cell inserted. This programs the egg into behaving as if it had been fertilized and it can grow into a embryo. It was not easy. The researchers used 304 eggs from 14 rhesus macaque monkeys and ended up with just two stem cell lines.

This means a lot more work before this would be useful for humans, they said -- especially given how hard human eggs are to come by. Tests show the embryonic stem cells are truly pluripotent, Mitalipov said, meaning they can develop into any kind of cell found in the body.

"We have been able to develop them into heart cells," he said. They also grew nerve cells.

It was important to confirm the work. A rival journal, Science, was forced to withdraw papers published by South Korean scientist Hwang Woo-suk in 2004 and 2005 after his claims to have cloned a human embryo proved false.

Mitalipov said the team has tried, and failed, to produce cloned monkeys that could grow into live baby monkeys.

"We have a goal also of producing live monkeys using the somatic cell nuclear transfer technique," he said. "One reason is to generate genetically modified macaques that, for example, carry a specific disease that is a model of human disease."

His team will not try to clone humans, he said.

"However we hope the techniques we develop will be useful for other labs which are working ... with human eggs," he said.

(Editing by Julie Steenhuysen and Cynthia Osterman)

((Maggie.Fox@Reuters.com; 1 202 898 8492)) Keywords: CLONING MONKEYS

(C) Reuters 2007. All rights reserved. Republication or redistribution ofReuters content, including by caching, framing or similar means, is expresslyprohibited without the prior written consent of Reuters. Reuters and the Reuterssphere logo are registered trademarks and trademarks of the Reuters group ofcompanies around the world.nN14558000

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Unregistered
15-11-07, 05:29
Uyghur biologiye alimi Shöhret Mutelliptin xelqimiz pexirlinidu we anilliimizning yene minglighan Shöhret Mutelliplerni tughup yitishturidighanliqigha ishinidu.




Researchers get stem cells from cloned monkeys


(Updates with quotes from researcher, details)

By Maggie Fox, Health and Science Editor

WASHINGTON, Nov 14 (Reuters) - U.S. researchers have cloned monkeys and used the resulting embryos to get embryonic stem cells, an important step towards being able to do the same thing in humans, they reported on Wednesday.

Shoukhrat Mitalipov and colleagues at Oregon Health & Science University said they used skin cells from monkeys to create cloned embryos, and then extracted embryonic stem cells from these days-old embryos.

This had only been done in mice before, they reported in the journal Nature. Mitalipov had given sketchy details of his work at a conference in Australia in June, but the work has now been independently verified by another team of experts.

They said their work shows it is possible, in principle, to clone humans and get stem cells from the embryos. "The efficiency is still low but I am quite sure that it will work in humans," Mitalipov told reporters in a telephone briefing.

Embryonic stem cells are the source of every cell, tissue and organ in the body. Scientists study them to understand the biology of disease and want to use them to transform medicine.

The idea would be to take a small piece of skin from a patient and grow tissue or even organ transplants perfectly matched to the patient.

But their use is controversial, with opponents saying it is wrong to use a human embryo in this way. U.S. President George W. Bush has repeatedly blocked legislation that would expand federal funding of such research.

OVERCOMING BARRIERS

Many species of animals have been cloned, and experts have taken stem cells from a variety of embryos, including human embryos. But it has been very difficult to both clone and then get embryonic stem cells from any animal.

Mitalipov's team overcame two barriers -- first cloning a primate, the group of mammals that includes monkeys, apes and humans, and then getting embryonic stem cells from the clone.

Mitalipov said the dyes used in cloning some animals apparently are toxic to primate cells.

They used somatic cell nuclear transfer, which involves taking the nucleus from an adult cell, in this case fibroblasts, a type of skin cell, taken from nine adult males.

Then an egg cell is hollowed out and the nucleus from the adult cell inserted. This programs the egg into behaving as if it had been fertilized and it can grow into a embryo. It was not easy. The researchers used 304 eggs from 14 rhesus macaque monkeys and ended up with just two stem cell lines.

This means a lot more work before this would be useful for humans, they said -- especially given how hard human eggs are to come by. Tests show the embryonic stem cells are truly pluripotent, Mitalipov said, meaning they can develop into any kind of cell found in the body.

"We have been able to develop them into heart cells," he said. They also grew nerve cells.

It was important to confirm the work. A rival journal, Science, was forced to withdraw papers published by South Korean scientist Hwang Woo-suk in 2004 and 2005 after his claims to have cloned a human embryo proved false.

Mitalipov said the team has tried, and failed, to produce cloned monkeys that could grow into live baby monkeys.

"We have a goal also of producing live monkeys using the somatic cell nuclear transfer technique," he said. "One reason is to generate genetically modified macaques that, for example, carry a specific disease that is a model of human disease."

His team will not try to clone humans, he said.

"However we hope the techniques we develop will be useful for other labs which are working ... with human eggs," he said.

(Editing by Julie Steenhuysen and Cynthia Osterman)

((Maggie.Fox@Reuters.com; 1 202 898 8492)) Keywords: CLONING MONKEYS

(C) Reuters 2007. All rights reserved. Republication or redistribution ofReuters content, including by caching, framing or similar means, is expresslyprohibited without the prior written consent of Reuters. Reuters and the Reuterssphere logo are registered trademarks and trademarks of the Reuters group ofcompanies around the world.nN14558000

Menbe: http://www.reuters.com/article/health-SP-A/idUSN1455800020071114?pageNumber=1

http://biliwal.com/modules.php?name=Forums&file=viewtopic&p=5624#5624

Wolf island
15-11-07, 11:40
Mitalipove apandiga mubarak bolsun! Unung utughi muxu sapta tirixip ixlawatkan Uyghur kasipdaxlargha zor ilham boldi, wa Uyghur larning ismi tunji bolup Nature gha ohxax top journal larda kozga korandi!

Unregistered
15-11-07, 12:32
Shokrat Mutallipni qin konglumdin tabriklayman.
Iltimas: Bilidighanlar bolsa bu adamning terjimalini yezip koysanglar.Rahmat.

Unregistered
15-11-07, 13:02
www.biliwal.com öz yazmisi: Uyghur Biologiye Alimi Shöhret Mitalip (Shoukhrat Mitalipov) Qazaqistanning Almuta shehiride tughulghan bolup, 1995-yili Amérika Qoshma Shtatlirigha kelgen. U 1987-yili Rusiyining Moskwa shehiridiki Timiriasev Akadémiyiside (Timiriasev Academy) Köpiyish Biologiyisi pénidin Magistérliq unwanigha érishken. 1994-yili yene Rusiye Tibbiy Penler Akadémiyisining (Russian Academy of Medical Sciences) Tébbiy Génétika Tetqiqat Merkizide Yétilish Génétikisi (Developmental Genetics) we Ghol hüjeyre (Stem Cell) Biologiyisi pénide doktorluq unwani alghan. Kéyin u Gérmaniyining Muenster Uniwérsitétigha kélip Ghol hüjeyre we Gén Tereqqiyati biologiye üstide doktor ashti basquchidiki tetqiqat bilen shughullan’ghan.

Doktor Shoukhrat Mitalipov 1995-yili Amérikidiki Uta Uniwérsitétigha kelgen we 1998-yili Orégon Shitatigha yötkilip, hazirghiche Oregon Shitatidiki döletlik Maymun türidiki haywanat Tetqiqat Merkizidiki Köpeytish Téxnologiyisi we törelme gewde hüjeyrisi Merkizi Tejribixanisi we Oregon Saghlamliq Penliri Uniwérsitétining Orégon hüjeyre Merkizide yardemchi proféssor bolup ishlewatidu. U hazir Maymun türidiki haywanlarning Gén Tereqqiyati, törelme ghol hüjeyre (ES cell) qatarliq tetqiqatlar bilen shughulliniwatidu. Ghol hüjeyre: toqulma we ichki organlargha tereqqiy qilish aldidiki deslepki hüjeyridur. Yeni bir tal hüjeyre nurghun hüjeyrige köpiyish jeryanida özgirip ketmey eslidiki mahiyitini saqlap turidighan hüjeyridin ibaret. Törelme gewde hüjeyrisi: herqandaq toqulmighimu tereqqiy qilalaydighan, köpiyish iqtidari yuqiri bolghan hüjeyre bolup, uruq qobul qilghan tuxumda peyda bolidu. Bu ES hüjeyre her xil hüjeyrige tereqqiy qilalaydighanliqi üchün, iqtidarini yoqatqan ichki ezalar we hüjeyrilerning ornini toluqlash nahayiti muhim dep qarilip, tetqiqatlar ishlenmekte. Lékin klinikida resmi ishlitishke téxi waqit kétishi mümkin.
Uning tehrirdin ötken (Xelq'arada yaki Amérikidiki yighinlarda oqughan maqalisidin sirt) maqalisi 26 parche, 4 parche kitab yazghan. Bir paténti bar. Hazir 6 tetqiqat türini ishlewatidu. 3 tetqiqatqa iltimas qilip qoyuqluq. Bir tetqiqatni ishlep püttürgen. Doktor Shoukhrat Mitalipov haywanlarning Gén Tereqqiyati we törelme gewde hüjeyre tetqiqatida dunyada aldinqi qatarda turmaqta.


Uning ayali Gülnur Nasirowamu Almutiliq bolup, ularning Linda we Nergiz isimlik ikki qizi we Paul isimlik bir oghli bar.


Biz Alimimiz Shoukhrat Mitalipovning téximu zor netijilerni qolgha keltürüshige tilekdashmiz.

Töwendikiler alim Shöhret Mitalip alghan tetqiqat türliri, yazghan maqaliliri, patént, hazir ishlewatqan tetqiqat türliri hem yazghan kitabliridin ibaret.


RESEARCH AWARDS



CURRENT


R01-RR16030-05 (PI Mitalipov) 7/01/01-6/30/07


NIH/NCRR, “Propagation of Monkey Models of Human Disease”
Major goal is to propagate Mamu A-01 positive animals through application of the ARTS.

R01-NS044330-04 (PI Mitalipov) 8/15/02-6/30/07


NIH/NINDS, “Genetically Modified Rhesus Monkeys”
The working hypothesis of this project is that gene targeting and somatic cell cloning technology can, in combination, provide the basis for generating a reliable supply of animals that accurately represent human disease. The objective is to create the infrastructure necessary to genetically modify rhesus monkey cells in culture and to use those cells as donors for nuclear transfer. The resultant viable embryos of the desired genotype can then be transferred into surrogate mothers. Genetically modified rhesus macaques will result. Such animals should provide a resource for the study of human neurogenetic diseases and serve as pre-clinical models for new experimental treatments including gene and stem cell based therapies.


R01 HD47721 (Reijo Pera, PI; Subcontract Mitalipov) 4/01/05 to 03/31/10


NIH/NICHD, “Genetic Analysis of Germ Cell Formation”
The major goal of this project is to use human embryonic stem cells (hESCs) to specifically probe the genetics of germ cell formation in vitro and in vivo using federally approved hESC lines and a primate model.


P51-RR0013-47 (PI Kohler) 5/1/04-4/30/09


NIH/NCRR, Subproject ART Core (Co PI’s Mitalipov; Stouffer)
The major goal of this project is to maintain the Assisted Reproductive Technologies (ART) core program at include all aspects of the ARTs in monkeys. The development component of the Core includes improving embryo culture conditions and non-surgical embryo transfer protocols.


P51-RR00163-47 (PI Kohler) 5/1/04-4/30/09


NIH/NCRR, Subproject ESC Core (Co PI’s Mitalipov; Stouffer)
The major goal of this project is to maintain the Embryonic Stem Cell (ESC) Core program including all aspects of primate ESC derivation, propagation and characterization. The research component of the Core includes improving ESC culture conditions and protocols for introduction of genetic modifications into primate ESCs



U54 HD18185-23 Center in Reproduction Research (PI Stouffer, Co PI Mitalipov) 4/1/04 -3/31/09

NIH/NICHD “Cooperative Research on Infertility in Primates”
The goal of this Specialized Cooperative Center is to address the causes and cures of human infertility disorders as they relate to neural, gonadal and gamete deficits.


PENDING


R24 (PI Mitalipov) 7/1/07-6/30/12


NIH/NCRR, “Rhesus monkey ESC lines for transplantation studies”
The goal of this project is to generate a rhesus monkey ESC bank consisting of up to 25 novel extensively characterized ESC lines suitable for transplantation research as a resource to the scientific community. Cell lines carrying the GFP reporter gene will be produced that will allow efficient selection, purification and tracking of ESCs and ESC-derived phenotypes before and after transplantation into recipient animals. Both parthenote-derived (mono-parental) and fertilized (bi-parental) cell lines will be created and their imprinting status will be characterized. For the first time, pluripotency of primate ESCs will be evaluated in vivo by quantitating the participation of ESC progeny in chimeric monkeys.


Stem Cell Research Foundation (PI Mitalipov) 7/1/07-6/30/09


“Primate Parthenogenetic ESCs for transplantation”
The aim of the present proposal is to generate important new insights concerning the genetic and epigenetic constitution of parthenogenetic ESCs in the NHP model in anticipation of clinical use of ESCs in the cell-based therapy of human diseases. Our working hypothesis is that primate parthenogenetic ESCs hold great potential as an isogenic source of immunologically compatible cells for treatment of degenerative diseases in a large cohort of the female population.


R24 (PI Mitalipov) 7/1/07-6/30/12


NIH/NCRR, “Propagation of Monkey Models of Human Disease”
The objective of this resource development proposal is to continue the application of the ARTs to the rapid and efficient propagation of Mamu-A*01 homozygous founder males and to demonstrate that the ARTs can be utilized for the rapid identification of new founders, either Mamu-A*01 or other haplotypes. The research component of this proposal represents a multidimensional attack on a problem relevant to the production of genetically-identical NHPs using nuclear transfer.


COMPLETED


2P51 RR00163-45 (PI Kohler) 5/1/02-4/30/04


NIH Support for Primate Center, Subproject (PI Mitalipov)
“Gene Expression and DNA Methylation Patterns in Rhesus Monkey Embryos and ES Cells”
The main objective of this proposal is to determine the onset of embryonic genome activation, gene expression and DNA methylation profiles during preimplantation development in rhesus monkey embryos. Another goal is to examine allele-specific expression and methylation patterns of four imprinted genes in monkey embryos and ES cells.



PATENTS:



”A Method of Producing Non-Human Transgenic Primates”, Houswirth W, Bunger J, Burns K, Neuringer M, Wolf D, Mitalipov S. United States Patent and Trademark Office. Application No.60/602,812. Filed August 3, 2004.



PEER-REVIEWED PUBLICATIONS:



Mitalipov S, Clepper L, Sritanaudomchai H, Fujimoto A, Wolf D. Methylation Status of Imprinting Centers for H19/IGF2 and SNURF/SNRPN in Primate Embryonic Stem Cells. Stem Cells. 2007 Mar;25(3):581-8. PMID: 17170068



Sritanaudomchai H, Pavasuthipaisit K, Kitiyanant Y, Kupradinun P, Mitalipov S, Kusamran T. Characterization and multilineage differentiation of embryonic stem cells derived from a buffalo parthenogenetic embryo. Mol Reprod Dev. 2007 Feb 8



Rajesh D, Chinnasamy N, Mitalipov SM, Wolf DP, Slukvin I, Thomson JA, Shaaban AF. Differential requirements for hematopoietic commitment between human and rhesus embryonic stem cells.
Stem Cells. 2007 Feb;25(2):490-9. PMID: 17284653



Byrne JA, Mitalipov SM, Clepper L, Wolf DP. Transcriptional Profiling of Rhesus Monkey Embryonic Stem Cells. Biol Reprod. 2006 Dec;75(6):908-15.

Mitalipov SM. Genomic imprinting in primate embryos and embryonic stem cells. Reprod Fertil Dev.
2006;18(8):817-21.



Byrne JA, Mitalipov SM, Wolf DP. Current progress with primate embryonic stem cell research. Current Stem Cell Research and Therapy. 2006. Volume 1, Number 2, May 2006. Pp. 127-138



Zhou Q, Yang SH, Ding CH, He XC, Xie YH, Hildebrandt TB, Mitalipov SM, Tang XH, Wolf DP, Ji WZ. A comparative approach to somatic cell nuclear transfer in the rhesus monkey. Hum Reprod. 2006 Oct;21(10):2564-71



Mitalipov S, Kuo HC, Byrne J, Clepper L, Meisner L, Johnson J, Zeier R, Wolf D. Isolation and characterization of novel rhesus monkey embryonic stem cell lines. Stem Cells. 2006 Oct;24(10):2177-86



Fujimoto A, Mitalipov SM, Kuo HC, Wolf DP. Aberrant genomic imprinting in rhesus monkey ES cells. Stem Cells. 2006 Mar;24(3):595-603.



Fluckiger AC, Marcy G, Marchand M, Negre D, Cosset FL, Mitalipov S, Wolf D, Savatier P, Dehay C. Cell cycle features of primate embryonic stem cells. Stem Cells. 2006 Mar;24(3):547-56.



Fujimoto A, Mitalipov SM, Clepper LL, Wolf DP. Development of a monkey model for the study of primate genomic imprinting. Mol Hum Reprod. 2005 Jun;11(6):413-22. Epub 2005 May 20



Yeoman RR, Mitalipov S, Gerami-Naini B, Nusser KD, Wolf DP. Low temperature storage of rhesus monkey spermatozoa and fertility evaluation by intracytoplasmic injection. Theriogenology. 2005 Jun;63(9):2356-71.



Wolf DP, Thormahlen S, Ramsey C, Yeoman R, Fanton J, Mitalipov S. Use of Assisted Reproductive Technologies in the Propagation of Rhesus Macaque Offspring. Biol Reprod. 2004 Aug;71(2):486-93.



Mitalipov SM, Kuo HC, Hennebold JD, Wolf DP. Oct-4 expression in pluripotent cells of the rhesus monkey. Biol Reprod. 2003 Dec;69(6):1785-92.



Kuo HC, Pau KYF, Yeoman RY, Mitalipov SM, Okano H. and Wolf DP. Differentiation of monkey embryonic stem cells into neural lineages. Biol Reprod. 2003 May;68(5):1727-35



Mitalipov SM, Nusser KD, Yeoman RR, Wolf DP. Rhesus monkey embryos produced by nuclear transfer from embryonic blastomeres or somatic cells. Biol Reprod. 2002 May;66(5):1367-73.



Mitalipov SM, Yeoman RR. Kuo H-C, Wolf DP. Monozygotic twinning in rhesus monkeys by manipulation of in vitro derived embryos. Biol Reprod. 2002 May; 66(5):1449-55.



Wolf DP, Mitalipov SM, Norgren RB. Nuclear transfer technology in Mammalian cloning. Arch Med Res. 2001 Nov;32(6):609-13.



Yeoman RR, Gerami-Naini B, Mitalipov S, Nusser KD, Widmann-Browning AA, Wolf DP. Cryoloop vitrification yields superior survival of rhesus monkey blastocysts. Hum Reprod. 2001 Sep;16(9):1965-9.



Mitalipov SM, Nusser KD, Wolf DP. Parthenogenetic activation of rhesus monkey oocytes and reconstructed embryos. Biol Reprod. 2001 Jul; 65(1):253-9.



Nusser KD, Mitalipov S, Widmann A, Gerami-Naini B, Yeoman RR, Wolf DP. Developmental competence of oocytes after ICSI in the rhesus monkey. Hum Reprod. 2001 Jan;16(1):130-137.



Mitalipov SM, Wolf DP. Mammalian cloning: possibilities and threats. Ann Med. 2000 Oct;32(7):462-8.



Mitalipov SM, White KL, Farrar VR, Morrey J, Reed WA. Development of nuclear transfer and parthenogenetic rabbit embryos activated with inositol 1,4,5-trisphosphate. Biol Reprod. 1999 Apr;60(4):821-7.



White KL, Bunch T.D, Mitalipov S.M, Reed WA. Establishment of pregnancy after the transfer of nuclear transfer embryos produced from the fusion of argali (Ovis ammon) nuclei into domestic sheep (Ovis aries) enucleated oocytes. Cloning. 1999. Vol.1 N.1:47-54.



Mitalipov SM, Mitallipova MM, Ivanov VI. The effect of the duration of culturing on the pluripotency of mouse embryonic stem (ES) cells in vitro and in vivo. Ontogenez. 1994 Nov-Dec;25(6):19-27. (Russian)



Mitalipov SM, Fedorov LM, Strel'chenko NS. An analysis of chimeric mice obtained by the injection of the inner cell mass into the blastocyst. Ontogenez. 1993 Sep-Oct;24(5):5-10. (Russian)



BOOK CHAPTERS:



Mitalipov SM, Wolf DP. Nuclear transfer in non-human primates. In: Nuclear transfer protocols: Cell reprogramming and transgenesis. Methods in Molecular Biology. Human Press. Edited by Verma PJ and Trounson AO. June 2006. ISBN: 1-58829-280-0



Mitalipov SM, Kuo HC, Wolf DP. The mammalian blastocysts as an experimental model. In: An atlas of human blastocysts. The Parthenon Publishing Group. New York, NY. Edited by Veeck LL and Zaninovic N. 2003. 231-250



Wolf DP, Mitalipov SM. Cloning mammals. In: Assisted Reproductive Technology. Accomplishments and New Horizons. Published by Cambridge University Press. Cambridge CB2 2RU. Edited by Christopher J. De Jonge and Christopher L.R. Barratt, 2002. 206-216.



White K L, Bunch T D, Mitalipov SM , Reed WA.. Application of ARTs and nuclear transfer in exotic or endangered species. In: Assisted fertilization and nuclear transfer in mammals. Series in Contemporary Endocrinology published by Humana Press. Edited by: D. Wolf and M. Zelinski-Wooten. 2001. 239-252.



Teyyarlighuchi: Dr. Tashpolat Rozi


Tehrir: Muxbir


Menbe: http://biliwal.com/modules.php?name=News&file=article&sid=1264

Mezkur maqala 2007-yili 03-ayning 17-kuni Biliwal torbetining Mutexessislirimiz sehipiside elan qilinghan.

Unregistered
15-11-07, 13:06
Shokrat Mutallipni menmu chin konglumdin tebrikleymen. U Uyghur xelqighe shan sherep ekeldi. Uning sozligen sozliri CNN, New York Times, BBC, Reuter, Yahoo qatarliq chong axbirat xewerliride berildi. Alimimiz Shohretning tenining salamet bolishini yenimu chong muwapiqiyetlerni qolgha kelturishini chin konglumdin umit qilimen.

Biliwal toridin shohretning terjimalini kordum. Ulinish towendikidekken:

http://biliwal.com/GoogleTap_SG_article_1264__0_0.html


Kanadadiki qerindisinglardin.


Shokrat Mutallipni qin konglumdin tabriklayman.
Iltimas: Bilidighanlar bolsa bu adamning terjimalini yezip koysanglar.Rahmat.

Unregistered
15-11-07, 15:05
Shohret Mutellipov, siz ozingizning emgigi bilen dunyagha Uyghur digen milletning alimlirimu barlighini jakarlidingiz.
Tunugun siz toghrilik hewerlerni her tereptin anglighinimda sizge qin konglumdin rehmetlerni eyttim. Bizge ohshash okughuqilargha hekiki muwakkiyitingiz bilen roh ata kiliwatisiz. Siz Uyghur iqidin qikkan hekiki alim. Sizni qin konglumdin tebrikleymen.

Uyghur Scientist
15-11-07, 15:34
Mana bu yerdin Shoukrat Mitalipov ning muxbirlar bilen ötküzgen video söhbitini körüng:

http://blog.oregonlive.com/multimedia/2007/11/researcher_describes_cloning_b.html

Unregistered
15-11-07, 15:45
Shokrat Mutallipni qin konglumdin tabriklayman.
Iltimas: Bilidighanlar bolsa bu adamning terjimalini yezip koysanglar.Rahmat.


BU qedirlik alimimizni chin yurektin tebrikleymen.

U QAZAQSTANNING UYGHUR-RAYONI diki kichik bir yezida oqutquchi ailiside dunyagha kelgen.
tepsilatini RFA ning uning singlisi we ailisini elip barghan telfon sohbitidin anglang.

Unregistered
15-11-07, 23:22
Dr. Shohretning netijisidin chin konglumdin pehirlendim. Mushundaq bir boskunchi tetqiqat sahasining eng aldida mengiwatqan kishining Uyghur bolghanlighigha heqiqeten ademning ishengusi kelmeydu. Chunki Amrikida Uyghurlar sani jehettin eng az wekillik qilinghan millet hisaplinidu. 10 milyon Uyghurgha wakaliten peqet 700 etrapida Uyghur bar. Bu tetqiqat sahesining nime uchun putun dunyaning diqitini shunche tartidighanlighidin yahshi hewerdar emesler uchun tuwende qisqiche chushendurup otey.

Dr. Shohretning yitekchiligidiki tetqiqat grupisining dunyada tunji bulup praymeytni (ademler ahilisidiki haywanlar) klon qilishi bir-neche kundin biri dunyadiki putun Englishche gezit we tilivzorlirida hewer qilip birildi. Ularning netijisi ademlerni klon qilishning achquqluq qedimi bolghachqa bu hewer ghayet zor hewer hisaplinidu. Stem Cell tetqiqati hazir dunyada eng dangliq we pen-tehnika yengiliqlirining eng aldinqi sepide turidighan tetqiqat. Chunki u ilimpenning chekini bosupla qalmastin belki insanliqning chek-chigrisinimu bosudighan we insaniyetning nime ikenligige qayte eniqlima biridighan bir pen. Bu tetqiqat Dr. Shohret eyitqandek nurghun kisellerni dawalash mumkin bolupla qalmastin belki qeriliqnimu dawalap insanlarning menggu yashishigha yol echishi mumkin. Yeni, huddi mashinining konirighan zapchaslirini yengisi bilen yengushlep menggu heydigili bolghandek stem cellmu kisel bolghan yaki konirighan (qerighan) organlarni yengisi bilen almashturup menggu yashashqa mumkinchilik achidu. Yene bir jehettin bu tehnika hem ademlerning uzini kopeytiwelishigha (klon qilishqa) mumkinchilik yaratqanlighi uchun jemmiyette nurghun qarshiliqqa uchrimaqta, bolupmu dinni zatlar ichide. Prezident Bushmu embroyonik stem cell tetqiqatini qollimaydighanlighini kop qetim buldurdi. Kishilerning ensirigini hehler Maykil Jorden yaki Bill Geyttek qabiliyetlik ademlerni tejirbehanida kopeytish arqiliq 100 hetta minglarche Maykel Jorden we Bill Gatelerni yasishi mumkin; Mustebit dowletlerning diktarotliri, meslen Shimali Koriyening prezidenti, Kubaning prezidenti qatarliq eski ademler ozlirini kopeytip yaman ademlerning yamrap kitishini kelturp chiqirishi mumkin; Puli bar eski ademler uzini kopeytiwelishi mumkin; Puli bar baylar menggu yashap puli yoqlar olup kitishi mumkin; kishiler er-hotun bolup bala tapqandin kore uzini kopeytiwelishi mumkin........

Bu tetqiqat manu mushuningdek kishining eqli yetmeydighan iktimalliqlargha yol achqanlighi uchun putun jemiyetning kozi tikilmekte. Bugun putun dunya hayajanlinish we qorqush ichide Dr. Shohretke tikildi. Hayajanlanghanlar bu tetqiqat nurghun kisellerge shipa ekilidu dep hayajanlanmaqta; qorqighanlar bolsa bu tetqiqat insaniyetning mahitini zogertiwitidu, huddi Eynistiyinning atom neziryesi tetqiqati alim umut qilghandek insaniyetning inirgiye ihtiyajini hel qilmastin belki yoqitish kuchi eng yuquri bolghan atom bombisining barliqqa kilishige sewepchi bolghandek insanlargha elip kilidighan ziyini paydisidin kop bolidu dep qorqidu. Siz qaysi topta turishingizdin qetti nezer bu sahediki bashqa alimlar kop yillardin biri terishipmu hujutqa kelturelmeywatwan bosush haraktirlik bu netijini bir Uyghurning mewjutqa kelturgini her qandaq Uyghurni hayajanlandurmay qalmaydu. Uyghurlargha purset bolsa nimini qilalmaydu? Kim Uyghurlarni dunyagha tesir korsitelmeydu deydikin emdi!!!! Tehimu zor utuqlar.

Unregistered
16-11-07, 12:20
Yaraysiz Uyghur Alimi Shohret Mitelip!

Unregistered
16-05-13, 07:35
UYGUR TURK ALIMI MITALIP EFENDI TABRIKLAR , UGUR SOYLU (Turkiye Turku ) - TAMPA-FLORIDA-USA (TURKATAM@YAHOO.COM)






Researchers get stem cells from cloned monkeys


(Updates with quotes from researcher, details)

By Maggie Fox, Health and Science Editor

WASHINGTON, Nov 14 (Reuters) - U.S. researchers have cloned monkeys and used the resulting embryos to get embryonic stem cells, an important step towards being able to do the same thing in humans, they reported on Wednesday.

Shoukhrat Mitalipov and colleagues at Oregon Health & Science University said they used skin cells from monkeys to create cloned embryos, and then extracted embryonic stem cells from these days-old embryos.

This had only been done in mice before, they reported in the journal Nature. Mitalipov had given sketchy details of his work at a conference in Australia in June, but the work has now been independently verified by another team of experts.

They said their work shows it is possible, in principle, to clone humans and get stem cells from the embryos. "The efficiency is still low but I am quite sure that it will work in humans," Mitalipov told reporters in a telephone briefing.

Embryonic stem cells are the source of every cell, tissue and organ in the body. Scientists study them to understand the biology of disease and want to use them to transform medicine.

The idea would be to take a small piece of skin from a patient and grow tissue or even organ transplants perfectly matched to the patient.

But their use is controversial, with opponents saying it is wrong to use a human embryo in this way. U.S. President George W. Bush has repeatedly blocked legislation that would expand federal funding of such research.

OVERCOMING BARRIERS

Many species of animals have been cloned, and experts have taken stem cells from a variety of embryos, including human embryos. But it has been very difficult to both clone and then get embryonic stem cells from any animal.

Mitalipov's team overcame two barriers -- first cloning a primate, the group of mammals that includes monkeys, apes and humans, and then getting embryonic stem cells from the clone.

Mitalipov said the dyes used in cloning some animals apparently are toxic to primate cells.

They used somatic cell nuclear transfer, which involves taking the nucleus from an adult cell, in this case fibroblasts, a type of skin cell, taken from nine adult males.

Then an egg cell is hollowed out and the nucleus from the adult cell inserted. This programs the egg into behaving as if it had been fertilized and it can grow into a embryo. It was not easy. The researchers used 304 eggs from 14 rhesus macaque monkeys and ended up with just two stem cell lines.

This means a lot more work before this would be useful for humans, they said -- especially given how hard human eggs are to come by. Tests show the embryonic stem cells are truly pluripotent, Mitalipov said, meaning they can develop into any kind of cell found in the body.

"We have been able to develop them into heart cells," he said. They also grew nerve cells.

It was important to confirm the work. A rival journal, Science, was forced to withdraw papers published by South Korean scientist Hwang Woo-suk in 2004 and 2005 after his claims to have cloned a human embryo proved false.

Mitalipov said the team has tried, and failed, to produce cloned monkeys that could grow into live baby monkeys.

"We have a goal also of producing live monkeys using the somatic cell nuclear transfer technique," he said. "One reason is to generate genetically modified macaques that, for example, carry a specific disease that is a model of human disease."

His team will not try to clone humans, he said.

"However we hope the techniques we develop will be useful for other labs which are working ... with human eggs," he said.

(Editing by Julie Steenhuysen and Cynthia Osterman)

((Maggie.Fox@Reuters.com; 1 202 898 8492)) Keywords: CLONING MONKEYS

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Menbe: http://www.reuters.com/article/health-SP-A/idUSN1455800020071114?pageNumber=1

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